Citations 0
Off-Center Fold
October 2000

Purplish Papules on the Legs

Author Affiliations

Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Dermatol. 2000;136(10):1263-1268. doi:

Microscopic examination showed dilated vessels throughout the dermis and subcutis, with intravascular collections of pale-pink homogeneous material and erythrocytes at the periphery of the vessel lumina. Despite vascular obstruction by these deposits, the overlying epidermis appeared viable. In the dermis, there was a sparse perivascular infiltrate of mixed inflammatory cells, scattered extravasated erythrocytes, and prominent edema. Stains for amyloid were negative. Microscopic findings were consistent with type I cryoglobulinemia. Evaluation of a serum sample revealed the presence of cryoglobulins. A computed tomographic scan of the thorax, abdomen, and pelvis demonstrated no abnormalities.

First Page Preview View Large
First page PDF preview
First page PDF preview