A 67-year-old white woman presented with a 4-year history of a nodule on her left leg. She reported that the nodule had increased in size over the previous several months. There was a history of clear drainage from the lesion. The patient was otherwise asymptomatic. Her medical history was significant for hypertension, which had been controlled with amlodipine. She had no history of skin cancer.
Physical examination revealed a 2.0-cm, firm, rubbery, violaceous nodule on the lateral aspect of the left knee (Figure 1). The lesion had a central ulceration, with serosanguineous fluid expressed from the center. Mobility was noted on palpation. There was no lymphadenopathy.
Neuhaus IM, Hassanein AM, Skidmore RA. Solitary Ulcerated Nodule on the Leg. Arch Dermatol. 2000;136(11):1409-1414. doi: