The epidermis was uninvolved. In the deep dermis, there was a large nodule composed of large atypical lymphoid cells with numerous mitotic figures and small lymphocytes. The atypical cells stained strongly with Ki-1 (CD30) immunoperoxidase (Figure 4). The patient was treated with chemotherapy (cyclophosphamide, vincristine, doxorubicin, and prednisone) and radiation therapy. The nodules completely cleared within 4 months; however, the patient subsequently developed crops of small erythematous papules that demonstrated the microscopic features of lymphomatoid papulosis. She was treated with tetracycline and UV-B therapy, with partial response.
Red Nodules on the Arm of a Patient With Breast Cancer. Arch Dermatol. 2000;136(12):1559-1564. doi: