A 2-year-old girl was referred to our department for skin fragility since early infancy. She had 2 older brothers, and the family had no medical history of note. Physical examination revealed mild xerosis with superficial skin erosions and erythematous residual macules from previous erosions. Some of the lesions had an unusual linear geographic contour and were predominantly located at areas of friction (Figure, A and B). Hair, nails, and mucous membranes were normal. There was no history of blistering. The mother explained that she often found the child peeling off skin with marked facility. Symptoms improved in winter and worsened in summer. Physical and mental developments were normal. Serological markers for celiac disease were negative. A skin biopsy was performed (Figure, C).
Mir-Bonafe JF, Baselga-Torres E, Gonzalez-Sarmiento R. A 2-Year-Old Girl With Skin Fragility. JAMA Dermatol. 2015;151(2):225-226. doi:10.1001/jamadermatol.2014.2772