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March 2010

Combined Multifocal Indeterminate Cell Histiocytosis and Basal Cell Carcinoma

Author Affiliations

Author Affiliations: Department of Dermatology, Loma Linda University, Loma Linda, California (Dr Strahan); Colorado Permanente Medical Group PC, Denver, Colorado (Dr Chorny); AboutSkin Dermatology, Englewood, Colorado (Dr Cohen); and Department of Dermatology, University of Colorado at Denver, Aurora (Dr Fujita).

Arch Dermatol. 2010;146(3):346-347. doi:10.1001/archdermatol.2010.13

An 85-year-old white man with a history of nonmelanoma skin cancer including basal cell carcinomas (BCCs) and a remote history of smoking 50 years ago presented with a 1.4-cm nodule of the right neck and an incisional biopsy was performed (Figure 1). The biopsy specimen showed nodular BCC with a dense infiltrate of histiocytic cells that tested positive with S-100 and CD1a immunostains, consistent with Langerhans cell histiocytosis (LCH) (Figure 2A-C). However, the cells tested negative with a langerin immunostain (Figure 2D) and positive with CD68. Electron microscopy (EM) was not performed. The collision tumor was completely excised.

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