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June 2010

A Case of Intravascular Large B-Cell Lymphoma With Atypical Clinical Manifestations and Analysis of CXCL12 and CXCR4 Expression

Author Affiliations

Author Affiliations: Department of Dermatology (Drs Nakajima, Miyachi, and Kabashima) and Center for Innovation in Immunoregulative Technology and Therapeutics (Dr Kabashima), Kyoto University Graduate School of Medicine, and Department of Pathology, Mitsubishi Kyoto Hospital (Dr Kyogoku), Kyoto, Japan; and Department of Pathology, School of Medicine, Kurume University, Kurume, Japan (Dr Ohshima).

Arch Dermatol. 2010;146(6):686-687. doi:10.1001/archdermatol.2010.113

Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive disease. Clinical cutaneous manifestations include purpuric to red macules, plaques, or nodules. Aggregation of atypical large B cells confined within the vascular lumen is the salient histologic characteristic, but the mechanism underlying this vessel-associated infiltration remains unexplained.1,2

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