Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin carcinoma.1 Owing to the recent isolation of a new human polyomavirus from MCC called Merkel cell polyomavirus (MCV),2 this malignancy has attracted much attention. Meanwhile, several groups have confirmed that MCV is detectable in 70% to 80% of MCC. Herein, we report how sequencing of the MCV genome may help to discern between delayed metastasis and multiple primary MCCs.
Schrama D, Thiemann A, Houben R, Kähler KC, Becker JC, Hauschild A. Distinction of 2 Different Primary Merkel Cell Carcinomas in 1 Patient by Merkel Cell Polyomavirus Genome Analysis. Arch Dermatol. 2010;146(6):687-689. doi:10.1001/archdermatol.2010.121