MARY S.STONEMDSOONBAHRAMIMDCARRIE ANN R.CUSACKMDSENAIT W.DYSONMDMOLLY A.HINSHAWMDVINCENTLIUMD
The histologic examination showed hyperkeratosis and acanthosis. Keratinocytes in the spinous and granular layers exhibited a clear cytoplasm with prominent blue-gray keratohyalin granules and intranuclear vacuoles, suggesting viral infection. Architectural and cytologic atypia were also noted in the epidermis. The superficial dermis showed a slight perivascular lymphocytic infiltrate. Human papillomavirus (HPV) DNA analysis was performed by polymerase chain reaction in the affected skin; HPV-14 and HPV-17 were detected.
Severe Palmoplantar Keratoderma—Diagnosis. Arch Dermatol. 2010;146(6):667-672. doi:10.1001/archdermatol.2010.116-b