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June 2010

Severe Palmoplantar Keratoderma—Diagnosis

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Arch Dermatol. 2010;146(6):667-672. doi:10.1001/archdermatol.2010.116-b

The histologic examination showed hyperkeratosis and acanthosis. Keratinocytes in the spinous and granular layers exhibited a clear cytoplasm with prominent blue-gray keratohyalin granules and intranuclear vacuoles, suggesting viral infection. Architectural and cytologic atypia were also noted in the epidermis. The superficial dermis showed a slight perivascular lymphocytic infiltrate. Human papillomavirus (HPV) DNA analysis was performed by polymerase chain reaction in the affected skin; HPV-14 and HPV-17 were detected.

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