[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.130.145. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
Off-Center Fold
June 2010

Severe Palmoplantar Keratoderma—Diagnosis

Author Affiliations
 

MARY S.STONEMDSOONBAHRAMIMDCARRIE ANN R.CUSACKMDSENAIT W.DYSONMDMOLLY A.HINSHAWMDVINCENTLIUMD

Arch Dermatol. 2010;146(6):667-672. doi:10.1001/archdermatol.2010.116-b

The histologic examination showed hyperkeratosis and acanthosis. Keratinocytes in the spinous and granular layers exhibited a clear cytoplasm with prominent blue-gray keratohyalin granules and intranuclear vacuoles, suggesting viral infection. Architectural and cytologic atypia were also noted in the epidermis. The superficial dermis showed a slight perivascular lymphocytic infiltrate. Human papillomavirus (HPV) DNA analysis was performed by polymerase chain reaction in the affected skin; HPV-14 and HPV-17 were detected.

First Page Preview View Large
First page PDF preview
First page PDF preview
×