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Drug-induced subacute cutaneous lupus erythematosus (DISCLE) presents similar clinical and serological characteristics to idiopathic SCLE. The following report describes a case of DISCLE induced by mitotane.
A woman in her 60s was diagnosed with a nonfunctioning stage II right adrenocortical carcinoma (ACC) and began treatment with mitotane (300 mg, 3 times daily) with supplementary hydrocortisone (200 mg/d). One month later, she had developed an itchy eruption without systemic involvement and she was referred for dermatologic consult.
Mayor-Ibarguren A, Roldán-Puchalt MC, Gómez-Fernández C, Albízuri-Prado F, Álvarez-Escola C. Subacute Cutaneous Lupus Erythematosus Induced by Mitotane. JAMA Dermatol. 2016;152(1):109-111. doi:10.1001/jamadermatol.2015.2702