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January 2016

Subacute Cutaneous Lupus Erythematosus Induced by Mitotane

Author Affiliations
  • 1Department of Dermatology, La Paz Hospital, Madrid, Spain
  • 2Department of Endocrinology, La Paz Hospital, Madrid, Spain

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Dermatol. 2016;152(1):109-111. doi:10.1001/jamadermatol.2015.2702

Drug-induced subacute cutaneous lupus erythematosus (DISCLE) presents similar clinical and serological characteristics to idiopathic SCLE. The following report describes a case of DISCLE induced by mitotane.

A woman in her 60s was diagnosed with a nonfunctioning stage II right adrenocortical carcinoma (ACC) and began treatment with mitotane (300 mg, 3 times daily) with supplementary hydrocortisone (200 mg/d). One month later, she had developed an itchy eruption without systemic involvement and she was referred for dermatologic consult.

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