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JAMA Dermatology Clinicopathological Challenge
December 2015

Rapidly Growing, Painful Nodule on the Upper Cutaneous Lip

Author Affiliations
  • 1Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia
  • 2Northeast Ohio Medical University, Rootstown
JAMA Dermatol. 2015;151(12):1365-1366. doi:10.1001/jamadermatol.2015.2878

A 41-year-old woman presented with a rapidly growing, painful nodule on her upper cutaneous lip (Figure, A) as well as several smaller papules on her face and neck, all of which had developed within the preceding 6 months. She was otherwise asymptomatic.

The patient’s medical history included diabetes mellitus type 2, hypercholesterolemia, hypertension, and depression. Review of her family medical history revealed that her paternal grandfather died from melanoma and that her father died from colon cancer. She stated that most of the men in her family had died from some form of cancer by the fourth decade of life.

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