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February 2016

BRAF Inhibition in a Lung Transplant Recipient With Metastatic Melanoma

Author Affiliations
  • 1Institute for General Practice, Hannover Medical School, Hannover, Germany
  • 2Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
  • 3Department of Pulmonary Medicine, Hannover Medical School, Hannover, Germany
  • 4Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Dermatol. 2016;152(2):228-230. doi:10.1001/jamadermatol.2015.2910

New treatment options like the BRAF inhibitors have been established for immunocompetent patients with metastatic melanoma, but experience in organ transplant recipients is lacking.

A female double lung transplant recipient in her 60s with a standard triple immunosuppressive regimen (cyclosporine, mycophenolate mofetil, prednisolone) and chronic lung allograft dysfunction was diagnosed with metastatic melanoma and pulmonary (Figure 1A), mediastinal, hepatic, osseous, subcutaneous, and cerebral metastases (Figure 2A). A primary tumor could not be detected, and tumor cells harbored a BRAF V600E mutation. Tumor marker S100 was elevated to 0.545 µg/L (reference value, <0.105 µg/L).

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