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Research Letter
February 2016

Nevus Anemicus and Bier Spots in Tuberous Sclerosis Complex

Author Affiliations
  • 1Faculté de Médecine, Université de Strasbourg, Strasbourg, France
  • 2Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
JAMA Dermatol. 2016;152(2):217-218. doi:10.1001/jamadermatol.2015.3999

Vascular lesions, such as nevus anemicus and Bier spots, are benign functional abnormalities.13 Four patients described herein with tuberous sclerosis complex (TSC) had nevus anemicus or Bier spots.

A retrospective descriptive analysis was performed of skin signs in 29 sequential patients with TSC who were examined by the same dermatologist (D.L.) over 10 years. All patients had a definite diagnosis of TSC according to criteria from the 2012 International Tuberous Sclerosis Complex Consensus Statements.4 A detailed and complete dermatological examination was performed at least once in all patients. This type of study that does not involve invasive investigation but relies on a clinical examination performed during a regular consultation does not need the approval of an institutional review board under French law.

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