Vascular lesions, such as nevus anemicus and Bier spots, are benign functional abnormalities.1- 3 Four patients described herein with tuberous sclerosis complex (TSC) had nevus anemicus or Bier spots.
A retrospective descriptive analysis was performed of skin signs in 29 sequential patients with TSC who were examined by the same dermatologist (D.L.) over 10 years. All patients had a definite diagnosis of TSC according to criteria from the 2012 International Tuberous Sclerosis Complex Consensus Statements.4 A detailed and complete dermatological examination was performed at least once in all patients. This type of study that does not involve invasive investigation but relies on a clinical examination performed during a regular consultation does not need the approval of an institutional review board under French law.
Sachs C, Lipsker D. Nevus Anemicus and Bier Spots in Tuberous Sclerosis Complex. JAMA Dermatol. 2016;152(2):217-218. doi:10.1001/jamadermatol.2015.3999