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Comment & Response
December 2015

Association Between Leukemia and Topical Use of Pimecrolimus—Reply

Author Affiliations
  • 1Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia
  • 2Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia
  • 3Valeant Pharmaceuticals International, Bridgewater, New Jersey
JAMA Dermatol. 2015;151(12):1391-1392. doi:10.1001/jamadermatol.2015.3492

In Reply We thank Drs Yew and Tey for their interest in our study.1 We are, however, concerned about their interpretation of our study results. Secondary analyses, as well as interpretations of analyses that were not part of the original study design, can result in spurious conclusions. Our study was not designed to evaluate only individuals of aged 1 to 4 years and was not designed to specifically study acute lymphoblastic leukemia (ALL). The investigation was designed to study all cancer and lymphoma in children (aged 2 to 18 years) as a group who were or will be followed for up to 10 years.

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