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Comment & Response
December 2015

Time-Dependent Measurement of Adverse Events—Reply

Author Affiliations
  • 1Mt Zion Cancer Research Center, Department of Dermatology, University of California, San Francisco
  • 2Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy
  • 3Department of Dermatology, The Rudolfstiftung Hospital, Academic Teaching Hospital, Medical University Vienna, Vienna, Austria
JAMA Dermatol. 2015;151(12):1392-1393. doi:10.1001/jamadermatol.2015.3578

In Reply We write this letter in response to the comments by Hwang and colleagues on our study.1 First, we would like to point out that the Kaplan-Meier curves and the log-rank tests were only used to initially describe the distribution of adverse events (AEs) in different treatment regimens. Afterwards, as stated in “Methods” section and in the heading of our Figure 3, we used a multivariate Cox regression model, to account for the time-dependent nature of AEs.

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