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We describe for the first time, to our knowledge, a paradoxical reaction to terbinafine treatment in the context of dermatophyte infection due to Trichophyton interdigitale.
A child weighing 30 kg and without any comorbidities and allergies and not taking any long-term medications was seen for erythematous, infiltrating, well-demarcated skin lesions located on the face, chest, abdomen, and limbs (Figure, A). Mycological culture yielded growth of Trichophyton mentagrophytes. The fungus was identified as T interdigitale by sequence analysis of the internal transcribed spacer and the D1/D2 domains of the large-subunit (26S) rRNA gene within the rDNA cluster using the polymerase chain reaction sequencing described elsewhere.1 The patient reported frequent contact with stray cats.
Hryncewicz-Gwóźdź A, Wojciechowska-Zdrojowy M, Maj J, Baran W, Jagielski T. Paradoxical Reaction During a Course of Terbinafine Treatment of Trichophyton interdigitale Infection in a Child. JAMA Dermatol. 2016;152(3):342-343. doi:10.1001/jamadermatol.2015.4293