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Research Letter
December 16, 2015

The Role of Bone Scintigraphy in the Diagnosis of Calciphylaxis

Author Affiliations
  • 1Medical student at Harvard Medical School, Boston, Massachusetts, at the time of the study
  • 2now with Department of Medicine and Department of Dermatology and Cutaneous Surgery, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, Florida
  • 3Department of Radiology, Massachusetts General Hospital, Boston
  • 4Department of Dermatology, Massachusetts General Hospital, Boston
  • 5Department of Nephrology, Massachusetts General Hospital, Boston

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Dermatol. Published online December 16, 2015. doi:10.1001/jamadermatol.2015.4591

Calciphylaxis is a rare, life-threatening small vessel vasculopathy,1 predominantly seen in patients with end-stage renal disease (ESRD). Most physicians rely on clinical findings and risk factors to diagnose calciphylaxis. However, mimickers exist,2 and tissue biopsy can be helpful to differentiate these diseases. Unfortunately, histopathological confirmation sometimes requires multiple biopsies, resulting in delayed treatment and possibly propagating new lesion formation.3 A noninvasive early testing modality would be preferred.

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