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Calciphylaxis is a rare, life-threatening small vessel vasculopathy,1 predominantly seen in patients with end-stage renal disease (ESRD). Most physicians rely on clinical findings and risk factors to diagnose calciphylaxis. However, mimickers exist,2 and tissue biopsy can be helpful to differentiate these diseases. Unfortunately, histopathological confirmation sometimes requires multiple biopsies, resulting in delayed treatment and possibly propagating new lesion formation.3 A noninvasive early testing modality would be preferred.
Paul S, Rabito CA, Vedak P, Nigwekar SU, Kroshinsky D. The Role of Bone Scintigraphy in the Diagnosis of Calciphylaxis. JAMA Dermatol. Published online December 16, 2015. doi:10.1001/jamadermatol.2015.4591