A 65-year-old woman presented with a 5-year history of gradually increasing blue discoloration of her ears. She had mild knee arthralgia that was treated with nonsteroidal anti-inflammatory drugs (NSAIDs). She was seeing an ophthalmologist annually regarding brown spots on both eyes diagnosed as conjunctival nevi. No other family members were similarly affected. As an infant, her mother had taken her to their physician owing to dark discoloration of her diapers, but this was not investigated further.
Muttardi K, Rubin A, Brown VL. A Patient With Blue Ears. JAMA Dermatol. 2016;152(4):465-466. doi:10.1001/jamadermatol.2015.4861