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June 2016

Unilateral Axillary Toxic Erythema of Chemotherapy in a Patient With Previous Axillary Lymph Node DissectionImplications for Pathophysiology and Therapy

Author Affiliations
  • 1Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia
JAMA Dermatol. 2016;152(6):727-728. doi:10.1001/jamadermatol.2015.4905

Toxic erythema of chemotherapy (TEC) is a cutaneous eruption that occurs with the use of cytotoxic chemotherapy and that presents with painful or pruritic erythematous patches or plaques occurring symmetrically on the hands, feet, and/or intertriginous areas (groin, axilla, neck).1 The lesions are often red-brown and may have associated blistering or superficial desquamation. The eruption characteristically appears within 2 to 3 weeks of initiating chemotherapy and is dose dependent.2 The agents most often associated with TEC are cytarabine, anthracyclines, fluorouracil, taxanes, and methotrexate.1 To our knowledge, this is the first report of a unilateral presentation of TEC, with sparing of an axilla that had previously been exposed to lymph node dissection (ALND) and radiation therapy.

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