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Microneedles are microscopic needles capable of creating microchannels through the stratum corneum to improve transdermal drug delivery.1- 3 Microneedles have been shown1,2,4- 6 to enhance the delivery of topical anesthetics with use of in vitro and animal models. In this split-body, randomized clinical trial, we investigated whether pretreatment with microneedles enhanced the anesthetic effect produced by topical lidocaine cream, 4%.
Ornelas J, Foolad N, Shi V, Burney W, Sivamani RK. Effect of Microneedle Pretreatment on Topical AnesthesiaA Randomized Clinical Trial. JAMA Dermatol. 2016;152(4):476-477. doi:10.1001/jamadermatol.2015.5544