[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 550
Citations 0
Research Letter
April 2016

Effect of Microneedle Pretreatment on Topical AnesthesiaA Randomized Clinical Trial

Author Affiliations
  • 1Medical Student, School of Medicine, University of California, Davis, Sacramento
  • 2Department of Dermatology, University of California, Davis, Sacramento
JAMA Dermatol. 2016;152(4):476-477. doi:10.1001/jamadermatol.2015.5544

Microneedles are microscopic needles capable of creating microchannels through the stratum corneum to improve transdermal drug delivery.13 Microneedles have been shown1,2,46 to enhance the delivery of topical anesthetics with use of in vitro and animal models. In this split-body, randomized clinical trial, we investigated whether pretreatment with microneedles enhanced the anesthetic effect produced by topical lidocaine cream, 4%.

First Page Preview View Large
First page PDF preview
First page PDF preview