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Research Letter
April 2016

Effect of Microneedle Pretreatment on Topical AnesthesiaA Randomized Clinical Trial

Author Affiliations
  • 1Medical Student, School of Medicine, University of California, Davis, Sacramento
  • 2Department of Dermatology, University of California, Davis, Sacramento

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Dermatol. 2016;152(4):476-477. doi:10.1001/jamadermatol.2015.5544

Microneedles are microscopic needles capable of creating microchannels through the stratum corneum to improve transdermal drug delivery.13 Microneedles have been shown1,2,46 to enhance the delivery of topical anesthetics with use of in vitro and animal models. In this split-body, randomized clinical trial, we investigated whether pretreatment with microneedles enhanced the anesthetic effect produced by topical lidocaine cream, 4%.

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