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JAMA Dermatology Clinicopathological Challenge
April 2016

A 50-Year-Old Woman With Reticulate Hyperpigmentation

Author Affiliations
  • 1Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Dermatol. 2016;152(4):461-462. doi:10.1001/jamadermatol.2015.5095

A 50-year-old woman presented with a 20-year history of slowly progressive red-to-brown pruritic hyperkeratotic papules and reticulated hyperpigmentation involving her face, neck, chest, back, and upper and lower extremities (Figure, A and B). She was previously diagnosed with Darier disease after biopsy revealed acantholytic dyskeratosis. She was treated with fluorouracil and tazarotene, 0.1%, cream with mild improvement, but she continued to develop new lesions. Social, family, and past medical history were noncontributory. Physical examination revealed reddish-brown hyperkeratotic papules on the neck, trunk, and extremities and diffuse brown macules, many in a reticulated pattern, on the face, neck, trunk, and extremities. There were no nail or mucosal changes. Laboratory data was noncontributory. A punch biopsy specimen was collected from both the arm and trunk and histologic examination was performed (Figure, C and D).

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