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The evaluation of malignant changes in epidermolysis bullosa (EB) nevi remains a challenge for clinicians; herein, we introduce the idea of employing melanoma gene expression markers to aid in thorough histopathologic examination of suspicious EB nevi lesions.
A young girl with epidermolysis bullosa simplex (EBS) initially came under our care at age 4 years. Two years after her first presentation, she developed an irregular brown-black patch on her left lateral ankle. The lesion was a 3.6 × 3 cm triangular hyperpigmented, asymptomatic patch consisting of confluent mottled black and brown macules and several satellite lesions consistent with an EB nevus.
Ahn JW, Johnson K, Kohen LL, Chaffins ML, Shwayder T. Melanoma Gene Expression Markers for Surveillance of Epidermolysis Bullosa Nevi Malignant Transformation. JAMA Dermatol. 2016;152(5):584-586. doi:10.1001/jamadermatol.2015.5702