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May 2016

Melanoma Gene Expression Markers for Surveillance of Epidermolysis Bullosa Nevi Malignant Transformation

Author Affiliations
  • 1Washington University in St Louis School of Medicine, St Louis, Missouri
  • 2Department of Dermatology, Henry Ford Hospital, Detroit, Michigan
JAMA Dermatol. 2016;152(5):584-586. doi:10.1001/jamadermatol.2015.5702

The evaluation of malignant changes in epidermolysis bullosa (EB) nevi remains a challenge for clinicians; herein, we introduce the idea of employing melanoma gene expression markers to aid in thorough histopathologic examination of suspicious EB nevi lesions.

A young girl with epidermolysis bullosa simplex (EBS) initially came under our care at age 4 years. Two years after her first presentation, she developed an irregular brown-black patch on her left lateral ankle. The lesion was a 3.6 × 3 cm triangular hyperpigmented, asymptomatic patch consisting of confluent mottled black and brown macules and several satellite lesions consistent with an EB nevus.

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