As the pathogenesis behind neonatal lupus erythematosus (NLE) is thought to require both gestational factors, such as circulating maternal autoantibodies, and an underlying fetal genetic susceptibility,1 we report an informative case of cutaneous NLE involving an infant conceived through in vitro fertilization with a healthy oocyte donor and a gestational mother with Sjögren syndrome (SS), demonstrating that direct inheritance of genetic susceptibility from a mother afflicted with autoimmunity is not required for NLE.
Chiou AS, Sun G, Kim J, Wang KC, Marqueling AL. Cutaneous Neonatal Lupus Arising in an Infant Conceived From an Oocyte Donation Pregnancy. JAMA Dermatol. 2016;152(7):846-847. doi:10.1001/jamadermatol.2016.0001