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July 2016

Cutaneous Neonatal Lupus Arising in an Infant Conceived From an Oocyte Donation Pregnancy

Author Affiliations
  • 1Department of Dermatology, Stanford University School of Medicine, Palo Alto, California
  • 2Dermatology Medical Group of Oxnard and Camarillo, Camarillo, California
JAMA Dermatol. 2016;152(7):846-847. doi:10.1001/jamadermatol.2016.0001

As the pathogenesis behind neonatal lupus erythematosus (NLE) is thought to require both gestational factors, such as circulating maternal autoantibodies, and an underlying fetal genetic susceptibility,1 we report an informative case of cutaneous NLE involving an infant conceived through in vitro fertilization with a healthy oocyte donor and a gestational mother with Sjögren syndrome (SS), demonstrating that direct inheritance of genetic susceptibility from a mother afflicted with autoimmunity is not required for NLE.

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