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July 2016

Psoriasis, Type 2 Diabetes Mellitus, and ObesityWeighing the Evidence

Author Affiliations
  • 1Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Dermatol. 2016;152(7):753-754. doi:10.1001/jamadermatol.2016.0670

Psoriasis is a common, chronic inflammatory disease that is associated with an increased risk of cardiovascular, metabolic, and renal disease in a manner that varies with the severity of psoriasis and is often independent of traditional risk factors for these other diseases.1,2 The clinical significance of these associations is emphasized by premature death, particularly in patients with more severe psoriasis, in whom excess mortality is comparable to that seen in rheumatoid arthritis treated with disease-modifying medications.3 The association of psoriasis with type 2 diabetes mellitus and obesity has been extensively studied and has been the subject of numerous meta-analyses that clearly establish an association of psoriasis with both obesity and diabetes.

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