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Observation
September 2016

Life-Threatening Cutaneous Bleeding in Childhood Klippel-Trenaunay Syndrome Treated With Oral Sirolimus

Author Affiliations
  • 1Department of Dermatology, Saint-Eloi Hospital, University Hospital of Montpellier, Montpellier, France
  • 2University of Montpellier, Montpellier, France
  • 3INSERM U1058, Montpellier, France
  • 4Department of Radiology, Lapeyronie Hospital, University Hospital of Montpellier, Montpellier, France
  • 5Department of Pediatric Infantile Surgery, Lapeyronie Hospital, University Hospital of Montpellier, Montpellier, France
  • 6Department of Internal Medicine, Saint-Eloi Hospital, University Hospital of Montpellier, Montpellier, France
  • 7Department of Pediatric Oncology and Hematology, Arnaud de Villeneuve Hospital, University Hospital of Montpellier, Montpellier, France
JAMA Dermatol. 2016;152(9):1058-1059. doi:10.1001/jamadermatol.2016.1008

Klippel-Trenaunay syndrome (KTS) is characterized by the triad of cutaneous capillary malformations (port-wine stains), asymmetrical disturbed growth of soft tissues and/or bone, and venous and lymphatic malformations.1 Prolonged and recurrent cutaneous bleeding from ulceration of the capillary and/or venous and/or lymphatic malformation can be life-threatening.2 We report for the first time to our knowledge a case of Klippel-Trenaunay syndrome treated by oral sirolimus.

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