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October 2016

Management of Antiplatelet Allergy After Cardiac Stenting

Author Affiliations
  • 1Department of Dermatology, Oregon Health and Science University, Portland, Oregon
JAMA Dermatol. 2016;152(10):1169-1170. doi:10.1001/jamadermatol.2016.1983

Clopidogrel is an antiplatelet agent used to prevent in-stent thrombosis after percutaneous coronary intervention (PCI). Discontinuation of clopidogrel therapy within 1 month of PCI results in in-stent thrombosis in more than 25% of patients and is associated with high mortality.1 Up to 6% of patients will develop a clopidogrel allergy but remain dependent on antiplatelet agents to prevent in-stent thrombosis.24 We report a case of generalized bullous fixed drug eruption associated with clopidogrel and review the recommended management strategies for clopidogrel allergy.

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