Primary cutaneous gamma-delta T-cell lymphoma (GD-TCL) is a rare skin lymphoma with numerous clinical presentations. Cytotoxic features on histologic analysis and the T-cell receptor (TCR)-gamma expression on immunohistochemical analysis are clues that should raise suspicion for the diagnosis. Expression of CD30 can also be seen in some cases and should be evaluated because it allows for patients to be treated with brentuximab, as in the present case.
A man in his 40s presented with numerous partially ulcerated papules and small plaques on the trunk (Figure 1A) and extremities covering 35% of the total body surface area without peripheral lymphadenopathy. He also reported severe pruritus and weight loss of 10 pounds over the previous 6 months.
Rubio-Gonzalez B, Zain J, Garcia L, Rosen ST, Querfeld C. Cutaneous Gamma-Delta T-Cell Lymphoma Successfully Treated With Brentuximab Vedotin. JAMA Dermatol. 2016;152(12):1388-1390. doi:10.1001/jamadermatol.2016.3117