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January 2017

Immunoglobulin E Autoantibodies in Bullous Pemphigoid Detected by Immunoglobulin E Enzyme-Linked Immunosorbent Assays

Author Affiliations
  • 1Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan
  • 2Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan
  • 3Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
JAMA Dermatol. 2017;153(1):15-17. doi:10.1001/jamadermatol.2016.4593

Autoimmune bullous diseases (AIBDs) exhibit an immunoglobulin (Ig) G and/or IgA antibody response to various cutaneous autoantigens.1 Immunoglobulin G antibasement membrane zone autoantibodies in bullous pemphigoid (BP) sera react with BP180 and BP230.14 While the pathogenic role of BP180 was confirmed by various disease models,5,6 production of autoantibodies to BP230 was considered an epiphenomenon. The commercial availability of IgG enzyme-linked immunosorbent assays (ELISAs) for both BP180 and BP230 makes it possible to more closely examine this premise.3,4

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