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Consensus Statement
March 15, 2017

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation GuidelinesResults of a National Institutes of Health Working Group

Author Affiliations
  • 1Department of Dermatology, University of California, Davis, Sacramento
  • 2Department of Dermatology, University of California, San Francisco
  • 3Medical Genetics Center, Medical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
  • 4Department of Dermatology, University of Pennsylvania, Philadelphia
  • 5Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland
  • 6Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linko and Keelung
  • 7Department of Pediatrics, UMKC School of Medicine, Kansas City, Missouri
  • 8Food and Drug Administration, Silver Spring, Maryland
  • 9Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, England
  • 10Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center and University of Toronto, Toronto, Ontario, Canada
  • 11Department of Pharmacology, Khon Kaen University, Khon Kaen 40002, Thailand
  • 12Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
  • 13Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  • 14Allergy Immunology and Rheumatology Division, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • 15Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Mahidol University, Bangkok, Thailand
  • 16National Human Genome Research Institute, Rockville, Maryland
JAMA Dermatol. Published online March 15, 2017. doi:10.1001/jamadermatol.2017.0160
Abstract

Importance  Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are rare, acute, life-threatening dermatologic disorders involving the skin and mucous membranes. Research into these conditions is hampered by a lack of standardization of case reporting and data collection.

Objective  To establish a standardized case report form to facilitate comparisons and maintain data quality based on an international panel of SJS/TEN experts who performed a Delphi consensus-building exercise.

Evidence Review  The elements presented for committee scrutiny were adapted from previous case report forms and from PubMed literature searches of highly cited manuscripts pertaining to SJS/TEN. The expert opinions and experience of the members of the consensus group were included in the discussion.

Findings  Overall, 21 out of 29 experts who were invited to participate in the online Delphi exercise agreed to participate. Surveys at each stage were administered via an online survery software tool. For the first 2 Delphi rounds, results were analyzed using the Interpercentile Range Adjusted for Symmetry method and statements that passed consensus formulated a new case report form. For the third Delphi round, the case report form was presented to the committee, who agreed that it was “appropriate and useful” for documenting cases of SJS/TEN, making it more reliable and valuable for future research endeavors.

Conclusions and Relevance  With the consensus of international experts, a case report form for SJS/TEN has been created to help standardize the collection of patient information in future studies and the documentation of individual cases.

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