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Off-Center Fold
January 2005

Subcutaneous Nodules on the Face—Diagnosis

Arch Dermatol. 2005;141(1):93-98. doi:10.1001/archderm.141.1.93-h

An incisional skin biopsy specimen from the glabella showed a diffuse granulomatous infiltrate within the dermis and subcutis (Figure 3 and Figure 4). The infiltrate was composed of lymphocytes, plasma cells, histiocytes, and multinucleated giant cells with vacuolated spaces, giving the specimen a Swiss cheese–like appearance. Scattered asteroid bodies were noted. Energy-dispersive x-ray probe microanalysis demonstrated the presence of silicon.

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