The palatal lesion consisted of multiple papillary projections of parakeratinized squamous epithelium supported by stalks of mildly inflamed vascular connective tissue (Figure 3). The gingival lesion showed epithelium with parakeratosis, acanthosis, and areas of pseudoepitheliomatous hyperplasia. The connective tissue was infiltrated by inflammatory cells, mainly lymphocytes, plasmacytes, and histiocytes. Koilocytes were absent (Figure 4). The results of investigations for detection of human papillomavirus DNA using in situ hibridization and polymerase chain reaction were negative.
Confluent Palatal and Gingival Papules in a 17-Year-Old Patient—Diagnosis. Arch Dermatol. 2005;141(4):515-520. doi:10.1001/archderm.141.4.515-b