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May 2005

Asymptomatic Preauricular Nodule—Diagnosis

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Arch Dermatol. 2005;141(5):633-638. doi:10.1001/archderm.141.5.633-d

Histopathologic examination revealed a well-circumscribed basaloid skin tumor that was composed of islands of cells set in a very densely fibrotic stroma. The tumor islands had a peripheral palisade of basaloid cells, with the cells in the center having larger vesicular nuclei. A heavy lymphocytic infiltrate was present within the stroma and within the tumor islands.

In 1987, Santa Cruz and Barr1 first described cutaneous lymphadenoma as a “lymphoepithelial tumour” because of its dual cellular components of lymphoid and epithelial cells. In 1991, they published a study of 13 cases of this unusual entity, renaming it cutaneous lymphadenoma.2 Cutaneous lymphadenoma is a rare benign adnexal tumor that is characterized by a peculiar pattern of lobules of epithelial basaloid cells admixed with a dense lymphocytic and histiocytic intraepithelial cell population. The tumor, which is manifested clinically by a single small, nonulcerated, slowly enlarging nodule, usually located on the head, does not recur after complete surgical excision.3 The age at diagnosis ranges from 21 to 75 years, with an equal sex distribution.

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