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June 2005

Cell-Mediated Immunologic Mechanism and Severity of TEN

Arch Dermatol. 2005;141(6):775-776. doi:10.1001/archderm.141.6.775

Toxic epidermal necrolysis (TEN) is a rare life-threatening disease with an incidence in all countries where it has been studied of about 1 case per million population per year.1 Although rare, TEN remains a disease of great interest for dermatologists and other physicians for 3 main reasons: high mortality and morbidity rates, dramatic death of the epidermis through a mechanism that is not fully understood, and the fact that this potentially fatal disease is most often the result of an “allergic” reaction to a medication.

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