In 1955, Zoon1 described a benign condition of the vulva that was characterized by erythematous plaques composed of predominantly plasma cells. Since his initial case report, there have been 32 additional cases reported, using 3 synonyms: plasma cell vulvitis (PCV), Zoon vulvitis, and vulvitis circumscripta plasmacellularis.2,3 The most common symptoms associated with PCV are pruritis, pain, burning, and dyspareunia.2 While some case reports describe conservative medical treatments that have been effective, we report a case of PCV that was recalcitrant to all treatments except surgical resection.
Goldstein AT, Christopher K, Burrows LJ. Plasma Cell Vulvitis: A Rare Cause of Intractable Vulvar Pruritis. Arch Dermatol. 2005;141(6):789-790. doi:10.1001/archderm.141.6.789