We welcome the article by Lin et al,1 “Localized Pemphigus Foliaceus Induced by Topical Imiquimod Treatment,” the first case report of imiquimod-induced localized pemphigus foliaceus. Only 2 months after this first case report, a second one was published.2 We would like to address several aspects of the possible mechanisms involved in the induction of pemphigus foliaceus by topical imiquimod treatment.
Mashiah J, Brenner S. Possible Mechanisms in the Induction of Pemphigus Foliaceus by Topical Imiquimod Treatment. Arch Dermatol. 2005;141(7):908-909. doi:10.1001/archderm.141.7.908