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Correspondence
July 2005

The Carney Complex: Unusual Skin Findings and Recurrent Cardiac Myxoma

Arch Dermatol. 2005;141(7):916-918. doi:10.1001/archderm.141.7.916

The Carney complex (CNC) is a rare autosomal, dominantly inherited trait expressed as pigmented skin lesions; cardiac, cutaneous, and mucosal myxomas; and neural and functioning endocrine tumors causing endocrine overactivity.1 We describe the clinical course of an African-American woman with CNC and a hypopigmented skin lesion atypical for CNC who has undergone 7 operations to excise cardiac myxomas. She also has a novel mutation of the PRKAR1A gene, the genetic abnormality present in approximately two thirds of families with a history of CNC.2

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