The anatomical site is gaining new importance in the etiology of cutaneous melanoma. Divergent pathologic pathways of tumor development have recently been proposed according to body site, and site-dependent associations with traditional melanoma risk factors have been found.1 Most epidemiological analyses rely on the anatomical site coded by cancer registries, which comes from medical reports.2,3 But how accurate is this information? Ambiguity in assignment of anatomical site codes has anecdotally been pointed out, but body site misclassification in the databases of registries does not appear to have been comprehensively estimated.
VIGNETTES. Arch Dermatol. 2005;141(8):1047-1049. doi:10.1001/archderm.141.8.1047