We report a case of durable remission of chronic, recurrent oral aphthous ulcerations (RAUs) of the mouth during treatment with the antidepressant bupropion hydrochloride. In 1984, Rosenthal1 reported that RAUs resolved during treatment with the antidepressant phenelzine sulfate. Phenelzine is a monoamine oxidase inhibitor (MAOI) antidepressant. Our patient’s RAUs were not associated with Crohn disease (CD) or other systemic illness.
Kast RE, Altschuler EL. Bupropion and Chronic Aphthous Ulceration. Arch Dermatol. 2005;141(9):1167. doi:10.1001/archderm.141.9.1167-a