In their recent article, Kovach et al1 reported successful treatment of multicentric reticulohistiocytosis (MR) with etanercept. Their patient was treated with a 25-mg subcutaneous injection of etanercept biweekly, 20 mg of prednisone daily, and 15 mg of methotrexate by mouth weekly and showed improvement in skin and joint symptoms within 1 month. We report a less successful application of etanercept in the treatment of MR.
Lovelace K, Loyd A, Adelson D, Crowson N, Taylor JR, Cornelison R. Etanercept and the Treatment of Multicentric Reticulohistiocytosis. Arch Dermatol. 2005;141(9):1167-1168. doi:10.1001/archderm.141.9.1167-b