Docetaxel is a semisynthetic drug derived from the European yew tree Taxus baccata that acts by disrupting the microtubular network, promoting the assembly of tubulin into stable microtubules and inhibiting their disassembly. Leakage into surrounding tissues during intravenous administration has been classified as an irritant,1 but reports questioning a vesicant reaction have been published.2- 4 We present herein a case of extravasation followed by an intense local skin reaction.
VIGNETTES. Arch Dermatol. 2005;141(10):1326-1327. doi:10.1001/archderm.141.10.1326