The editorial by Burg et al1 is an illuminating and unifying exploration of preneoplastic dyscrasias that occur in multiple clinical contexts. As the authors state, the precise molecular events involved in the progression from dyscrasias to lymphomas remain unclear. One fundamental biological property of lymphocytes may underlie the mechanism by which genomically unstable “genotraumatic” cells bridge the transition from polyclonal activated lymphocytes to monoclonal populations to malignant clones.
Tsai KY. A Potential Pathogenic Role for Aberrant DNA Rearrangements in Bridging Dyscrasias of Undetermined Significance and Lymphoma?. Arch Dermatol. 2005;141(11):1468-1469. doi:10.1001/archderm.141.11.1468-b