Microscopic examination revealed a moderately intense superficial and deep perivascular and interstitial infiltrate composed of lymphocytes and plasma cells. The deep reticular dermis revealed sclerosis of the collagen bundles. The findings were consistent with an inflammatory stage of morphea. Metastatic breast carcinoma was not seen.
At the 2-week follow-up visit, it was observed that the patient’s condition had not improved without treatment. A 3-month course of twice-daily applications of 0.05% diflorasone diacetate cream was then initiated, and marked improvement in the erythema and induration at the biopsy site was noted after 6 weeks. Some residual retraction remained.
Breast Erythema and Induration in a 77-Year-Old Woman—Diagnosis. Arch Dermatol. 2006;142(1):101-106. doi:10.1001/archderm.142.1.101-d