A 51-year-old white woman presented to the dermatology outpatient clinic for a skin examination, during which a red papule was noted on her left breast. According to her medical history, the lesion had been present for 1 year and was asymptomatic. Her medical history was also notable for papillary carcinoma of the same breast 2 years earlier, which had been treated with breast conservation surgery and radiation therapy.
On physical examination, the lesion, which measured 4 mm in diameter (Figure 1), was firm, nontender, and erythematous. There was no clinical evidence of ulceration. The lesion was excised and stained with hematoxylin-eosin (Figure 2 and Figure 3).
Lowe J, Lu D, Heffernan MP. A Papule Arising in Irradiated Breast Tissue—Quiz Case. Arch Dermatol. 2006;142(1):101-106. doi:10.1001/archderm.142.1.101-e