Comments and Opinions
February 2006

A Seeming Failure of Logic

Author Affiliations

Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006

Arch Dermatol. 2006;142(2):243-253. doi:10.1001/archderm.142.2.244

I am perplexed by what seems to be a contradiction in conclusions drawn by the members of the Melanoma Center at the University of California, San Francisco, concerning prognosis of primary cutaneous melanoma. In a recent issue of the ARCHIVES, Shaikh et al write as follows1(p739):

The presence of microsatellites is intimately tied to other markers of melanoma aggressiveness. Microsatellites appear to predict locoregional relapse and RFS [relapse-free survival] but neither distant metastasis nor OS [overall survival].