Although the effectiveness of vaccination with BCG, an attenuated strain of Mycobacterium tuberculosis, has been challenged,1,2 the vaccine has been used in Japan since 1942. We describe a very rare case of a patient in whom BCG granuloma was identified by polymerase chain reaction (PCR)–based genomic deletion analysis more than 50 years after vaccination for BCG.
Seishima M, Fujisawa T, Yamanaka S, Ishii N, Mori S, Ohashi K, Suzutani T. BCG Granuloma Appearing More Than 50 Years After Vaccination. Arch Dermatol. 2006;142(2):243-253. doi:10.1001/archderm.142.2.249