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March 2006

Submucosal Nodule of the Tongue—Diagnosis

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Arch Dermatol. 2006;142(3):385-390. doi:10.1001/archderm.142.3.385-e

Microscopic examination revealed a discrete papillomatosis with irregular epithelial hyperplasia, acanthosis, and, in places, anastomosing epithelial ridges. On the surface, there was a layer of cells with a clear cytoplasm that was covered with a thin layer of parakeratosis in some areas. The underlying chorion was fibrotic and cicatricial, and in the middle of the fragment, among degenerating muscle fibers, there was a foreign body giant cell granuloma. The foreign material was birefringent under polarized light.

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