The histologic sections showed an intraepidermal blister, with confluent necrosis of the epidermis, resulting in eosinophilic reticular degeneration. Regenerating epidermis was seen at the periphery. Dermal papillary edema was evident, and dermal vessels at the base of the necrotic area were filled with red blood cell thrombi. There was also a moderately dense perivascular infiltrate of lymphocytes and histiocytes. The histologic findings were consistent with HV. The results of in situ hybridization for Epstein-Barr virus were negative.
Bullae on the Wrists of an 11-Year-Old Boy—Diagnosis. Arch Dermatol. 2006;142(4):515-520. doi:10.1001/archderm.142.4.515-h