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Evidence-Based Dermatology: Research Commentary
June 2006

Breakthrough in the Treatment of Warts?

Arch Dermatol. 2006;142(6):767-768. doi:10.1001/archderm.142.6.767

Question: Is α-lactalbumin–oleic acid (also known as HAMLET [human α-lactalbumin made lethal to tumor cells]) effective as a treatment for cutaneous viral warts?

Design: A randomized, placebo-controlled double-blind trial converting to an open label study after 3 months.

Setting: University dermatology department in Lund, Sweden.

Patients: Forty adults and children with refractory warts (defined as “papillomas resistant to conventional treatments”). Nine of the 40 patients were receiving immunosuppressive drugs.

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