Mycosis fungoides (MF), a cutaneous lymphoma with diverse clinical manifestations, rarely presents with vesiculobullous lesions, or MF bullosa (MFB). Mycosis fungoides with large cell transformation, transformed MF (T-MF), is also another rare condition. We report 2 cases of MFB, one of which was complicated with T-MF.
Case 1. A 72-year-old woman, who was first diagnosed as having MF in her fifties (Figure 1A and B), presented with multiple nodules on her back (Figure 1C). Skin specimens of a nodule showed atypical cells with enlarged, pale nuclei clustered in the dermis (Figure 1D).These malignant cells stained positive for CD30. She was diagnosed as having T-MF and was treated with psoralen plus UV-A (PUVA) and topical corticosteroids.
Natsuga K, Shimizu T, Abe R, Kodama K, Shimizu H. Mycosis Fungoides Bullosa. Arch Dermatol. 2006;142(6):781-798. doi:10.1001/archderm.142.6.793