Narrowband UV-B (NB UV-B) therapy has recently been shown to be effective in the repigmentation of patients with vitiligo, without significant adverse effects. In recent uncontrolled studies, topical tacrolimus therapy has also been reported to cause repigmentation of vitiligo lesions, particularly on the face and neck. To explore the possibility of synergism between these 2 modalities, we conducted a prospective, randomized, controlled trial of therapy with NB UV-B and tacrolimus or placebo for patients with generalized vitiligo.
Mehrabi D, Pandya AG. A Randomized, Placebo-Controlled, Double-blind Trial Comparing Narrowband UV-B Plus 0.1% Tacrolimus Ointment With Narrowband UV-B Plus Placebo in the Treatment of Generalized Vitiligo. Arch Dermatol. 2006;142(7):927-947. doi:10.1001/archderm.142.7.927