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Off-Center Fold
July 2006

Atrophic Congenital Lesion on the Back—Diagnosis

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Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006

Arch Dermatol. 2006;142(7):921-926. doi:10.1001/archderm.142.7.921-g

Histologically, the epidermis was focally atrophic, and the dermis was increased in thickness, showing a spindle-cell proliferation that extended into the subcutaneous fat and included a reduction of cutaneous adnexa as well as a moderate collagenous component. A mild increase in perivascular mast cells was also noted.

Immunohistochemical findings included CD34 and factor XIIIa immunoreactivity in a majority of spindle cells, suggesting a dermal dendritic cell phenotype of the proliferating population. The immunoreactivity of S100 protein and CD68 was not significant. An orcein stain demonstrated that elastic fibers were diminished.